![]() ![]() These results indicate an alteration in the composition of lipid and protein content of HDL from childhood ALL survivors with metabolic disorders. In addition, proteomic analyses revealed an enrichment of pro-thrombotic (e.g., fibrinogen) and pro-inflammatory (e.g., amyloid A) proteins in the HDLs deriving from metabolically unhealthy survivors. The HDL fraction from the survivors contained less cholesterol than the controls. HDLs from 8 metabolically healthy ALL survivors, 8 metabolically unhealthy ALL survivors and 8 age- and gender-matched controls were analyzed. The main objective of the present work was to characterize the composition of HDL particles isolated from pediatric ALL survivors. ![]() However, this achievement comes with many secondary and long-term effects since more than 65% of the survivors experience at least one severe complication, including the metabolic syndrome and cardiovascular diseases. With the use of more modern, efficient treatments, 5-year survival has reached more than 90% in this population. ![]() Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. ![]()
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